Pharmacokinetics of FK 506: preclinical and clinical studies.

Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients.

FK 506 is a new macrolide with potent immunosuppressive activity. Use of this drug is associated with reduced incidence of rejection following liver. kidney. and heart transplantation. 1-4 Recently, FK 506 has been shown to be effective in small bowel transplantation. S It is known that FK 506 absorption is not influenced by the presence or absence of bile.6--8 The aims of this study are to: (\...

Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations.

I N initial clinical trials of organ transplanta.tion, F~. 5~ has shown remarkable immunosuppressive activity. The drug is very lipophilic. metabolized in the liver, and predominantly eliminated through the bile. 2 Hepatic dysfunction was expected to alter the pharmacokinetics of FK 506. Hepatic dysfunction is also known to alter the absorption of lipid soluble drugs. 3 This is related to the l...

Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression.

OBJECTIVE The efficacy for primary orthotopic liver transplantation of a new immunosuppressive agent, FK 506 (tacrolimus, Prograf, Fujisawa USA, Deerfield, IL), was determined. SUMMARY BACKGROUND DATA After 3 years of preclinical research, a clinical trial of FK 506 for orthotopic liver transplantation was begun in February 1989, first as a rescue therapy for patients with intractable rejecti...

Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine.

Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm

Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages oflearning and memory the main aim of this study was t...